Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …

Autophagy is a cytoplasmic degradation system that is important for starvation adaptation
and cellular quality control. Previously, we reported that Atg5-null mice are neonatal lethal; …

Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …

Photoreceptors have high energy demands and a high density of mitochondria that produce
ATP through oxidative phosphorylation (OXPHOS) of fuel substrates. Although glucose is …

Neurons are highly polarized and post-mitotic cells with the specific requirements of
neurotransmission accompanied by high metabolic demands that create a unique challenge …

The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and
have the highest density of mitochondria of any cell in the body. Both physiological and …