Alzheimer's disease (AD) is a debilitating age-related neurodegenerative condition.
Unbiased genetic studies have implicated a central role for microglia, the resident innate …

Leukocytes sense extracellular ATP, a danger-associated molecular pattern, released
during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here …

Epigenetic changes in chromatin structure have been recently associated with the
deregulated expression of critical genes in normal and malignant processes. HDAC11, the …

Chronic heavy drinking (CHD) of alcohol is a known risk factor for increased susceptibility to
bacterial and viral infection as well as impaired wound healing. Evidence suggests that …

Overexpression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in different
types of cancer is associated with tumor growth and progression. Tumor necrosis factor-α …

Neuroinflammation underlies many neuro-degenerative diseases. In this paper, we report
the identification of a new pterocarpan-type anti-inflammatory compound named sophotokin …

Studies have established the association between increased plasma levels of matrix
metalloproteinase (MMP)-9 and adipose tissue inflammation. Tumor necrosis factor α …

Unlike polyphenols, which are widely available in the diet, polyacetylenes are available only
from the Apiaceae family vegetables, including carrot, parsnip, fennel, celery, and many …

The solid tumor microenvironment presents many challenges for immunotherapy that must
be addressed for clinical relevance. This review will highlight research that has attempted to …

Introduction: Lipopolysaccharide (LPS) is a systemic response-triggering endotoxin, which
has the kidney as one of its first targets, thus causing acute injuries to this organ. Physical …