Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

ACT Ng, V Delgado, BA Borlaug, JJ Bax - Nature Reviews Cardiology, 2021 - nature.com
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

[HTML][HTML] Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research

BM Leon, TM Maddox - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
The incidence of diabetes mellitus (DM) continues to rise and has quickly become one of the
most prevalent and costly chronic diseases worldwide. A close link exists between DM and …

Lipid metabolism and toxicity in the heart

IJ Goldberg, CM Trent, PC Schulze - Cell metabolism, 2012 - cell.com
The heart has both the greatest caloric needs and the most robust oxidation of fatty acids
(FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake …

Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy

M Zhao, H Wei, C Li, R Zhan, C Liu, J Gao, Y Yi… - Nature …, 2022 - nature.com
Numerous studies found intestinal microbiota alterations which are thought to affect the
development of various diseases through the production of gut-derived metabolites …

Diabetic cardiomyopathy: pathophysiology and clinical features

T Miki, S Yuda, H Kouzu, T Miura - Heart failure reviews, 2013 - Springer
Since diabetic cardiomyopathy was first reported four decades ago, substantial information
on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances …

Early detection of left atrial strain abnormalities by speckle-tracking in hypertensive and diabetic patients with normal left atrial size

S Mondillo, M Cameli, ML Caputo, M Lisi… - Journal of the American …, 2011 - Elsevier
BACKGROUND: Systemic hypertension and type 2 diabetes mellitus are associated with
impaired left atrial (LA) function, but whether LA functional abnormalities also occur in …

[HTML][HTML] Left atrial function: evaluation by strain analysis

GCH Gan, A Ferkh, A Boyd… - … diagnosis and therapy, 2018 - ncbi.nlm.nih.gov
The left atrium has an important role in modulating left ventricular filling and is an important
biomarker of cardiovascular disease and adverse cardiovascular outcomes. While …

The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics

A Li, L Lian, X Chen, W Cai, X Fan, Y Fan, T Li… - Free Radical Biology …, 2023 - Elsevier
Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus

E Levelt, CT Rodgers, WT Clarke… - European heart …, 2016 - academic.oup.com
Aims Patients with type 2 diabetes mellitus (T2DM) are known to have impaired resting
myocardial energetics and impaired myocardial perfusion reserve, even in the absence of …