Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Hyperandrogenism is the main cause of infertility as a result of polycystic ovary syndrome
(PCOS). Long-term and continuous exposure to hyperandrogen can cause follicular …

Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for
schizophrenia treatment during acute psychoses, but they are also indicated for …

The heavy metals (HMs) lead and cadmium are persistent environmental pollutants capable
of inducing ill-health in exposed individuals. One of the primary sites of accumulation and …

Excessive fluoride intake has a strong female reproductive toxicity, which can result in
follicular developmental dysplasia and decrease oocytes developmental potential. The …

Atypical antipsychotic (AA) medications including risperidone (RIS) and olanzapine (OLAN)
are FDA approved for the treatment of psychiatric disorders including schizophrenia, bipolar …

In this study, effects of icariin (Ica) on were examined in a mouse model of d-galactose (D-
gal)-induced ovarian aging. Kunming white mice were divided into three groups: aging …

Background Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have
been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist …

Chronic use of antipsychotic medications entails a dilemma between the benefit of
alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse …

Assessment of drug-induced mitochondrial dysfunctions is important in drug development as
well as in the understanding of molecular mechanism of therapeutic or adverse effects of …