The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Resveratrol, metabolic syndrome, and gut microbiota

A Chaplin, C Carpéné, J Mercader - Nutrients, 2018 - mdpi.com
Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic
syndrome-related alterations in experimental animals, including glucose and lipid …

[HTML][HTML] Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

BNM Zordoky, IM Robertson, JRB Dyck - Biochimica et Biophysica Acta …, 2015 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Despite advancements in
diagnosis and treatment of cardiovascular disease, the incidence of cardiovascular disease …

[HTML][HTML] The pharmacology of resveratrol in animals and humans

EJ Park, JM Pezzuto - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
In addition to thousands of research papers related to resveratrol (RSV), approximately 300
review articles have been published. Earlier research tended to focus on pharmacological …

New insights for oxidative stress and diabetes mellitus

K Maiese - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results

R Gal, L Deres, K Toth, R Halmosi, T Habon - International journal of …, 2021 - mdpi.com
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …

Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice

X Zhou, L He, C Wu, Y Zhang, X Wu… - Molecular Nutrition & …, 2017 - Wiley Online Library
Scope Serine lies at the central node linking biosynthetic flux from glycolysis to glutathione
synthesis and one‐carbon metabolic cycle which are closely related to antioxidant capacity …

[HTML][HTML] Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related …

X Zhou, L He, S Zuo, Y Zhang, D Wan, C Long… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Serine deficiency has been observed in patients with nonalcoholic fatty liver disease
(NAFLD). Whether serine supplementation has any beneficial effects on the prevention of …

Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats

R Kosuru, V Kandula, U Rai, S Prakash, Z Xia… - … drugs and therapy, 2018 - Springer
Purpose Oxidative stress has a pivotal role in the pathogenesis of diabetes-associated
cardiovascular problems, which has remained a primary cause of the increased morbidity …

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature

S Ghaffari, N Roshanravan - Food research international, 2020 - Elsevier
Hypertension (HTN) is a worldwide epidemic in both developed and developing countries. It
is one of the leading causes of major health problems such as cardiovascular disease …