Proteomics is a large-scale study of proteins, aiming at the description and characterization
of all expressed proteins in biological systems. The expressed proteins are typically highly …

Membrane proteins (MP s) play diverse biologically important structural and functional roles
including molecular transport, cell communication, and signal transduction. The dysfunctions …

To complement the recent genomic sequencing of Chinese hamster ovary (CHO) cells,
proteomic analysis was performed on CHO cells including the cellular proteome, secretome …

With the acceleration of proteome research, increasing attention has been paid to
multidimensional liquid chromatography–mass spectrometry (MDLC–MS) due to its high …

Better peptide separation is required for bottom-up proteomics for further improving the
proteome coverage. The two-dimensional liquid chromatography (2D-LC) systems only …

Despite the rapid development of liquid chromatography (LC) in recent decades, it remains
a challenge to achieve the desired chromatographic separation of complex matrices using a …

In-depth coverage of proteomic analysis could enhance our understanding to the
mechanism of the protein functions. Unfortunately, many highly hydrophobic proteins and …

Ionic liquids (ILs) as promising solvents have been quickly designed and applied in many
areas spanning from electrochemistry, energy, chemical synthesis and catalysis to …

Microfluidic system with multi-functional integration of high-throughput protein/peptide
separation ability has great potential for improving the identification capacity of biological …

Due to their extremely hydrophobic nature, the analysis of integral membrane proteins
(IMPs) is of great challenge. Although various additives have been applied to improve the …