Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

The tumor microenvironment (TME) comprises a variety of immune cells, among which T
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …

Muscle-residing regulatory T cells (Tregs) control local tissue integrity and function.
However, the molecular interface connecting Treg-based regulation with muscle function …

The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive
enhancer-binding protein, was originally identified as a key transcription factor involved in …

High-salt diets are associated with an elevated risk of autoimmune diseases, and immune
dysregulation plays a key role in cancer development. However, the correlation between …

Tonicity-responsive enhancer-binding protein (TonEBP), which is also known as nuclear
factor of activated T cells 5 (NFAT5), was discovered 20 years ago as a transcriptional …

In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet
autoimmunity, often many years before clinical symptoms arise. While T cells play a major …

The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel
homology domain-containing factors, which comprises the NF-κB proteins and the …

T cells responding to persistent tumor or viral antigens progressively lose their functional
properties, a feature known as exhaustion. This state is also characterized by cell-surface …

Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor‐(NF‐) κB family member,
is the only known gene regulator of the mammalian adaptive response to osmotic stress …