Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Introduction Diabetes is a well‐established risk factor for dementia, but its impact on the
prodromal phase of dementia is unclear. Methods Cohorts of older adults who were …

The construct of mild cognitive impairment (MCI) has evolved over the past 10 years since
the publication of the new MCI definition at the K ey S ymposium in 2003, but the core …

With the aging of the population, the burden of Alzheimer's disease (AD) is rapidly
expanding. More than 5 million people in the US alone are affected with AD and this number …

Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

Objective: Public health campaigns encouraging early help seeking have increased rates of
mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about …

Mild cognitive impairment (MCI) is the widely used term that describes an intermediate stage
from normal cognitive function to dementia. The concept of MCI is highly significant and …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Background: Cohort studies have reported that midlife high total serum cholesterol (TC) is
associated with increased risk of Alzheimer's disease (AD) in late-life but findings have been …