Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

Multifarious roles of sialic acids in immunity

A Varki, P Gagneux - Annals of the New York Academy of …, 2012 - Wiley Online Library
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Sialic acids as regulators of molecular and cellular interactions

R Schauer - Current opinion in structural biology, 2009 - Elsevier
The wide occurrence of sialic acids (Sia) in various chemical forms linked as monomers or
polymers in an outstanding position in a multitude of complex carbohydrates of animals and …

[PDF][PDF] Wang

Y Wang - Jia Z, Yi Q, Song L. The various components implied …, 2018 - tranassoc.com
Systems and methods are disclosed for communicating data in an integrated sensor network
having one or more nodes coupled to an optical sensor network and a radio frequency …

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

Targeted glycan degradation potentiates cellular immunotherapy for solid tumors

J Wu, X Wang, Y Huang, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Immune cell–based cancer therapies, such as chimeric antigen receptor T (CAR-T)-cell
immunotherapy, have demonstrated impressive potency against hematological tumors …

Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

RJ Solá, K Griebenow - BioDrugs, 2010 - Springer
During their development and administration, protein-based drugs routinely display
suboptimal therapeutic efficacies due to their poor physicochemical and pharmacological …

[HTML][HTML] Sialylation and galectin-3 in microglia-mediated neuroinflammation and neurodegeneration

M Puigdellívol, DH Allendorf, GC Brown - Frontiers in cellular …, 2020 - frontiersin.org
Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …

Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach

A Eon‐Duval, H Broly, R Gleixner - Biotechnology progress, 2012 - Wiley Online Library
Abstract Quality by Design (QbD) is a new approach to the development of recombinant
therapeutic protein products that promotes a better understanding of the product and its …

[HTML][HTML] Sialic acid and biology of life: An introduction

S Ghosh - Sialic acids and sialoglycoconjugates in the biology of …, 2020 - ncbi.nlm.nih.gov
Sialic acids are important molecule with high structural diversity. They are known to occur in
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …