Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that
are related to the construction and refinement of functional networks. During the …

Patterned, spontaneous activity occurs in many developing neural circuits, including the
retina, the cochlea, the spinal cord, the cerebellum and the hippocampus, where it provides …

The morphological and functional development of the vertebrate nervous system is initially
governed by genetic factors and subsequently refined by neuronal activity. However …

Before the onset of sensory transduction, developing neural circuits spontaneously generate
correlated activity in distinct spatial and temporal patterns. During this period of patterned …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation
during the prenatal, early postnatal, and adolescent periods. During these developmental …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

Brain connections are organized into topographic maps that are precisely aligned both
within and across modalities. This alignment facilitates coherent integration of different …

The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …