A comprehensive review of rosmarinic acid: From phytochemistry to pharmacology and its new insight

H Guan, W Luo, B Bao, Y Cao, F Cheng, S Yu, Q Fan… - Molecules, 2022 - mdpi.com
Polyphenolic acids are the widely occurring natural products in almost each herbal plant,
among which rosmarinic acid (RA, C18H16O8) is well-known, and is present in over 160 …

Therapeutic potential of rosmarinic acid: A comprehensive review

M Nadeem, M Imran, T Aslam Gondal, A Imran… - Applied Sciences, 2019 - mdpi.com
Naturally occurring food-derived active ingredients have received huge attention for their
chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) …

Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects

A Dahchour - Pharmacological Research, 2022 - Elsevier
Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

Rosmarinic acid: modes of action, medicinal values and health benefits

M Alagawany, ME Abd El-Hack, MR Farag… - Animal Health …, 2017 - cambridge.org
The supplementation of livestock rations with herbs containing bioactive components, such
as rosmarinic acid (RA), have shown promising results as a natural feed additive in …

Mitochondria in neuroprotection by phytochemicals: Bioactive polyphenols modulate mitochondrial apoptosis system, function and structure

M Naoi, Y Wu, M Shamoto-Nagai… - International journal of …, 2019 - mdpi.com
In aging and neurodegenerative diseases, loss of distinct type of neurons characterizes
disease-specific pathological and clinical features, and mitochondria play a pivotal role in …

Effects of rosmarinic acid on nervous system disorders: an updated review

M Ghasemzadeh Rahbardar… - … Archives of Pharmacology, 2020 - Springer
Nowadays, the worldwide interest is growing to use medicinal plants and their active
constituents to develop new potent medicines with fewer side effects. Precise dietary …

Plant-derived antioxidants protect the nervous system from aging by inhibiting oxidative stress

X Cui, Q Lin, Y Liang - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) has become a major disease contributing to human death and is
thought to be closely related to the aging process. The rich antioxidant substances in plants …

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of …

FJ Mirza, S Amber, D Hassan, T Ahmed, S Zahid - Phytomedicine, 2021 - Elsevier
Background Rosmarinus officinalis, commonly known as rosemary, is a medicinal herb that
presents significant biological properties such as antimicrobial, antioxidant, anti …

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB …

Z Ma, Y Lu, F Yang, S Li, X He, Y Gao, G Zhang… - Toxicology and Applied …, 2020 - Elsevier
Spinal cord injury (SCI) is a severe central nervous system injury for which few efficacious
drugs are available. Rosmarinic acid (RA), a water-soluble polyphenolic phytochemical, has …

[HTML][HTML] Neuroprotective Benefits of Rosmarinus officinalis and Its Bioactives against Alzheimer's and Parkinson's Diseases

D Kosmopoulou, MP Lafara, T Adamantidi… - Applied Sciences, 2024 - mdpi.com
Featured Application Utilization of Rosmarinus officinalis extracts and/or its bioactives as
ingredients in functional products, foods, cosmetics, and pharmaceuticals, with anti …