Systemic sclerosis interstitial lung disease: unmet needs and potential solutions

V Liakouli, A Ciancio, F Del Galdo… - Nature Reviews …, 2024 - nature.com
Systemic sclerosis (SSc), or scleroderma, is a rare, complex, systemic autoimmune disease
of unknown aetiology, characterized by high morbidity and mortality often resulting from …

Research Progress in pathogenesis of connective tissue disease-associated interstitial lung disease from the perspective of pulmonary cells

S Shen, M Hu, Y Peng, Y Zheng, R Zhang - Autoimmunity Reviews, 2024 - Elsevier
The lungs are a principal factor in the increased morbidity and mortality observed in patients
with Connective Tissue Disease (CTD), frequently presenting as CTD-associated Interstitial …

Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis

C Chêne, D Rongvaux-Gaïda, M Thomas… - Frontiers in …, 2023 - frontiersin.org
Introduction Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by
diffuse fibrosis of the skin and internal organs and vascular abnormalities. The etiology and …

Increase in double negative B lymphocytes in patients with systemic lupus erythematosus in remission and their correlation with early differentiated T lymphocyte …

E Moysidou, G Lioulios, M Christodoulou… - Current Issues in …, 2023 - mdpi.com
B and T lymphocytes demonstrate important alterations in patients with systemic lupus
erythematous (SLE), with a significant upregulation of double negative (DN) B cells. The aim …

Blocking BAFF Alleviates Hepatic Fibrosis in Schistosoma japonicum-Infected Mice

P Dong, C Mei, Y Yang, Y Zhou, Y Xu, L Song, C Yu - Pathogens, 2023 - mdpi.com
Schistosomiasis is an immunopathogenic disease characterized by egg granuloma and
fibrosis. The hepatic fibrosis of schistosomiasis is caused by the coordinated action of local …

Extended Inflammation Parameters (EIP) as Markers of Inflammation in Systemic Sclerosis

A Kowalska-Kępczyńska, M Mleczko… - International Journal …, 2024 - Wiley Online Library
Background. Systemic sclerosis (SSc) is an autoimmune disease characterized by
inflammation, progressive vasculopathy, and fibrosis of skin and internal organs. The aim of …

Radiation‐induced fibrosis: Mechanisms and therapeutic strategies from an immune microenvironment perspective

M Zheng, Z Liu, Y He - Immunology, 2024 - Wiley Online Library
Radiation‐induced fibrosis (RIF) is a severe chronic complication of radiotherapy (RT)
manifested by excessive extracellular matrix (ECM) components deposition within the …

Molecular Mechanisms Underlying Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: an Update

P Verma, S Bale, J Varga, S Bhattacharyya - Current Treatment Options in …, 2023 - Springer
Purpose of review Systemic sclerosis–associated interstitial lung disease (SSc-ILD) and
idiopathic pulmonary fibrosis (IPF) are fatal fibrotic lung disorders characterized by …

Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune …

E Rossi, M Lausen, N Friesgård Øbro, A Colque… - bioRxiv, 2023 - biorxiv.org
Polymicrobial airway infections and detrimental inflammation characterize patients with
cystic fibrosis (CF), a disease with heterogeneous clinical outcomes. How the overall …

Double Negative B lymphocytes are increased in patients with Systemic Lupus Erythematosus and they are correlated with early differentiated T lymphocyte …

E Moysidou, G Lioulios, M Christodoulou, A Xochelli… - 2023 - preprints.org
B and T lymphocytes demonstrate important alterations in patients with Systemic Lupus
Erythematous (SLE), with significant up-regulation of Double Negative (DN) B cells. Aim of …