Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

The formation of adipocytes from precursor stem cells involves a complex and highly
orchestrated programme of gene expression. Our understanding of the basic network of …

During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

The adipocyte-like morphology of clear cell renal cell carcinoma (ccRCC) cells results from a
grade-dependent neutral lipid accumulation; however, the molecular mechanism and role in …

Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of
adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired …

Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …

The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …

Background Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer.
The purpose of this study is to define a biological pathway signature and a cellular …

Excess or insufficient lipid storage in white adipose tissue lipid droplets is associated with
dyslipidemia, insulin resistance and increased risk for diabetes type 2. Thus, maintenance of …