I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

Uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) is the most
bothersome phenotype of chronic rhinosinusitis; it is typically characterized by a type 2 …

Novel therapies such as type 2 targeting biologics are emerging treatment options for
patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely …

Objectives/Hypothesis Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease
process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants
with different underlying pathophysiologies. Limited knowledge of the mechanisms of these …

Background Endoscopic sinus surgery (ESS) is a common operation for patients with
chronic rhinosinusitis with nasal polyps (CRSwNP) when medical therapy alone is …

Key Clinical Points Chronic Rhinosinusitis with Nasal Polyps Chronic rhinosinusitis with
nasal polyps typically manifests as nasal obstruction, reduction in sense of smell, nasal …

Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic
challenge because of the high recurrence rate. Surgical intervention should be considered …