Human T cells have a diverse T‐cell receptor (TCR) repertoire that endows them with the
ability to identify and defend against a broad spectrum of antigens. The universe of possible …

The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein
complexes encompassing tumor neoantigens provide a rationale for target selection …

Identifying highly specific T cell receptors (TCRs) or antibodies against epitopic peptides
presented by class I major histocompatibility complex (MHC I) proteins remains a bottleneck …

Effectively targeting intracellular tumor-associated proteins presents a formidable challenge
in oncology, as they are traditionally considered inaccessible to conventional antibody …

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide
loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to …

Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive
immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and …

HLA-DQ molecules drive unwanted alloimmune responses after solid-organ transplants and
several autoimmune diseases, including type 1 diabetes and celiac disease. Biologics with …

The genetic diversity of killer cell immunoglobulin‐like receptors (KIRs) and human
leukocyte antigen (HLA) genes influences the host's immune response to viral pathogens …

This work focuses on molecules that are encoded by the major histocompatibility complex
(MHC) and that bind self-, foreign-or tumor-derived peptides and display these at the cell …

Cancer is the primary cause of death worldwide, and conventional treatments are painful,
complicated, and have negative effects on healthy cells. However, cancer immunotherapy …