ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

CA Devaux, JM Rolain, D Raoult - Journal of Microbiology, Immunology …, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged in
Chinese people in December 2019 and has currently spread worldwide causing the COVID …

ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease

HO Singh, R Choudhari, V Nema, AA Khan - Microbial pathogenesis, 2021 - Elsevier
Background A carboxypeptidase protein called ACE2 is found in many organs. ACE2
protein can play a pivotal role to regulate the pathological changes of several diseases …

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

DS Pinheiro, RS Santos, PCBV Jardim, EG Silva… - PloS one, 2019 - journals.plos.org
Background Systemic arterial hypertension (SAH) is a multifactorial condition that already
affects one third of the worldwide population. The identification of candidate genes for …

Genetic hypothesis and pharmacogenetics side of renin-angiotensin-system in COVID-19

D Gemmati, V Tisato - Genes, 2020 - mdpi.com
The importance of host genetics and demography in coronavirus disease 2019 (COVID-19)
is a crucial aspect of infection, prognosis and associated case fatality rate. Individual genetic …

Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: an ecological meta-regression

N Hatami, S Ahi, A Sadeghinikoo, M Foroughian… - Endocrine, 2020 - Springer
With the emergence of the Novel Coronavirus (2019-nCoV), researchers worldwide have
started detecting the probable pathogenesis of the disease. The renin–angiotensin system …

Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: a case–control study

Q Zhang, M Cong, N Wang, X Li, H Zhang, K Zhang… - Medicine, 2018 - journals.lww.com
Abstract Angiotensin-converting enzyme 2 (ACE2) plays an important role in the
development of essential hypertension (EH). The aim of this study was to investigate the …

Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang

Y Luo, C Liu, T Guan, Y Li, Y Lai, F Li, H Zhao… - Hypertension …, 2019 - nature.com
Essential hypertension (EH) is a principal contributing factor in worldwide cardiovascular
disease mortality. Although interventions that minimize environmental risk factors for EH are …

An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019 …

CA Devaux, L Camoin-Jau - Frontiers in microbiology, 2022 - frontiersin.org
It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …

From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

SK Patel, E Velkoska, M Freeman, B Wai… - Frontiers in …, 2014 - frontiersin.org
Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and
the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS …

[HTML][HTML] ACE2 and TMPRSS2 SNPs as Determinants of Susceptibility to, and Severity of, a COVID-19 Infection

S Abdelsattar, ZA Kasemy, SF Ewida… - British Journal of …, 2022 - frontierspartnerships.org
Background: Genetic risk factors may be related to the infectivity and severity of SARS-CoV-
2 infection. Angiotensin-converting enzyme 2 (ACE2) and host transmembrane serine …