Revisiting Pyrimidine-Embedded Molecular Frameworks to Probe the Unexplored Chemical Space for Protein–Protein Interactions

JY Yoo, Y Choi, H Kim, SB Park - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Protein–protein interactions (PPIs) are essential in numerous biological
processes and diseases, making them attractive yet challenging drug targets. While many …

Synthesis of Seven-and Eight-Membered Rings by a Brønsted Acid Catalyzed Cationic Carbocyclization of Biphenyl Embedded Enynes

J Tostado, A Milián, JJ Vaquero… - Organic …, 2024 - ACS Publications
A Brønsted acid catalyzed cyclization of o-alkenyl-o′-alkynylbiaryls for the synthesis of
biologically relevant dibenzo-fused medium-sized rings has been developed. The outcome …

[HTML][HTML] Expedient synthesis of 8-membered azasultams: A combined synthetic, DFT, and in vitro study

HV Posternak, OD Semoshkina, VY Hys, DS Milokhov… - Tetrahedron Chem, 2024 - Elsevier
Herein we describe the novel approach to the synthesis of functionalized ind (az) olo-fused
1, 2, 4-thiadiazocine 1, 1-dioxides through the CSIC (Carbanion-mediated Sulfonate …

Aluminum-Catalyzed Intramolecular Vinylation of Arenes by Vinyl Cations

W Lin, A Alix, R Guillot, V Gandon, C Bour - Organic Letters, 2024 - ACS Publications
This study addresses the challenges associated with vinyl cation generation, a process that
traditionally requires quite specific counterions. Described herein is a novel intramolecular …

Rigid medium-sized rings: applications and synthesis

S Stenfors - 2024 - jyx.jyu.fi
The literature review section of this master's thesis focuses on the properties of compounds
with medium-sized rings, stereoselective synthesis strategies, occurrence in natural …

Synthesis of Strained Systems via Vinyl Carbocation Intermediates

ZS Zhao - 2025 - search.proquest.com
SYNTHESIS OF STRAINED SYSTEMS VIA VINYL CARBOCATION INTERMEDIATES Page 1
SYNTHESIS OF STRAINED SYSTEMS VIA VINYL CARBOCATION INTERMEDIATES Thesis …

[PDF][PDF] Tetrahedron Chem

HV Posternak, OD Semoshkina, VY Hys, DS Milokhov… - researchgate.net
Herein we describe the novel approach to the synthesis of functionalized ind (az) olo-fused
1, 2, 4-thiadiazocine 1, 1-dioxides through the CSIC (Carbanion-mediated Sulfonate …