The biggest challenge associated with cancer chemotherapy is the development of cross multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …
B Tinoush, I Shirdel, M Wink - Frontiers in Pharmacology, 2020 - frontiersin.org
Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers. MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of …
Brain tumors are an abnormal growth of cells in the brain, also known as multifactorial groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …
A Rafatmanesh, M Behjati, N Mobasseri… - Journal of Cellular …, 2020 - Wiley Online Library
Survivin is a member of the family of apoptosis inhibitory proteins with increased expression level in most cancerous tissues. Evidence shows that survivin plays regulatory roles in …
ZX He, TQ Zhao, YP Gong, X Zhang, LY Ma… - European Journal of …, 2020 - Elsevier
The multidrug resistance (MDR) phenomenon in cancer cells is the major obstacle leading to failure of chemotherapy accompanied by the feature of intractable and recurrence of …
A Sorf, J Hofman, R Kučera, F Staud… - Biochemical …, 2018 - Elsevier
Ribociclib is a novel cyclin-dependent kinase (CDK) 4 and 6 selective inhibitor that recently gained breakthrough therapy status and global approval for advanced breast cancer …
E Novotná, N Büküm, J Hofman, M Flaxová… - Biochemical …, 2018 - Elsevier
Members of the short-chain dehydrogenase/reductase (SDR) and aldo-keto reductase (AKR) superfamilies mediate the reduction of anthracyclines to their less potent C-13 alcohol …
J Hofman, A Sorf, D Vagiannis, S Sucha… - Molecular …, 2019 - ACS Publications
Brivanib, a promising tyrosine kinase inhibitor, is currently undergoing advanced stages of clinical evaluation for solid tumor therapy. In this work, we investigated possible interactions …
M Xiao, W Li - Current medicinal chemistry, 2015 - ingentaconnect.com
Survivin, a member of the inhibitor of apoptosis proteins family, is highly expressed in most human neoplasms, but its expression is very low or undetectable in terminally differentiated …