Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

The year 2023 marks the 25 th anniversary of the discovery of RNA interference (RNAi).
RNAi-based therapeutics enable sequence-specific gene knockdown by eliminating target …

Prime editor (PE), a new genome editing tool, can generate all 12 possible base-to-base
conversions, insertion, and deletion of short fragment DNA. PE has the potential to correct …

Diabetic retinopathy (DR) has characteristics of early loss of capillary pericytes, contributing
to aberrant endothelial proliferation and angiogenesis. The function of extracellular vesicles …

Genetic medicine is offering hope as new therapies are emerging for many previously
untreatable diseases. The eye is at the forefront of these advances, as exemplified by the …

Retinal vein occlusion (RVO) is the second most prevalent retinal disease. Despite this, the
pathogenic mechanisms and risk factors are not entirely clear. In this article, we review …

Purpose: Diabetic retinopathy (DR), a common microvascular complication of diabetes, is
the leading cause of acquired blindness in the working-age population. Individuals with …

Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying
macula is known to increase the risk of age-related macular degeneration (AMD). AMD is …

Age-related macular degeneration (AMD) is a complex and multifactorial disease and a
leading cause of irreversible blindness in the elderly population. The anti-vascular …

Acquired retinal diseases such as age-related macular degeneration and diabetic
retinopathy rank among the leading causes of blindness and visual loss worldwide. Effective …