Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

Subterranean mammals spend their lives in dark, unventilated environments that are rich in
carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived …

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly
due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and …

Naked mole‐rats (NMRs) have exceptional longevity and are resistant to age‐related
physiological decline and diseases. Given the role of cellular senescence in aging, we …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …

Significance: The oxidative stress theory of aging has been the most widely accepted theory
of aging providing insights into why we age and die for over 50 years, despite mounting …

Selenium (Se) is an essential trace element because of its presence in selenoproteins in the
form of selenocysteine residue. Both Se deficiency, which compromises selenoprotein …