Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …

A central tenet of the T-cell hypothesis of psoriasis is that lymphocytes can change
epidermal growth homeostasis, leading to increased keratinocyte proliferation and abnormal …

The balance between regulatory and effector functions is important for maintaining efficient
immune responses, while avoiding autoimmunity. The inflammatory skin disease psoriasis is …

Psoriasis vulgaris is a skin disease potentially mediated by pro-inflammatory cytokines
produced by type 1 lesional T cells. The capability of individual T cells to produce these …

It has been proposed that the development of insulin-dependent diabetes is controlled by
the T helper 1 (TH1) versus TH2 phenotype of autoreactive TH cells: TH1 cells would …

Psoriasis is a T cell–dependent autoimmune disease of the skin and joints. Disease
manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing …

Although the precise underlying pathomechanisms of psoriasis have not been fully
elucidated, previous reports suggest that T helper 1-type cytokines are critically involved in …

Type 2 cytokines are thought to have a protective role in psoriasis vulgaris by dampening
the activity of T helper 1 (Th1) lymphocytes. The aim of the present study was to determine …

BACKGROUND: Psoriasis is a chronic autoimmune hyperproliferative skin disease of
varying severity affecting approximately 2–3% of the general population in the USA and …

Evidence for a key role of T cells in the pathogenesis of psoriasis has come from both
experimental and clinical data. Initially, generalized immunosuppressants, intended for use …