Revolutionizing medicinal chemistry: the application of artificial intelligence (AI) in early drug discovery

R Han, H Yoon, G Kim, H Lee, Y Lee - Pharmaceuticals, 2023 - mdpi.com
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical
industry and research, where it has been utilized to efficiently identify new chemical entities …

Computational drug repurposing for viral infectious diseases: a case study on monkeypox

S Saha, P Chatterjee, M Nasipuri, S Basu… - Briefings in …, 2024 - academic.oup.com
The traditional method of drug reuse or repurposing has significantly contributed to the
identification of new antiviral compounds and therapeutic targets, enabling rapid response …

Assessment of GO-based protein interaction affinities in the large-scale human–coronavirus family interactome

SS Bandyopadhyay, AK Halder, S Saha, P Chatterjee… - Vaccines, 2023 - mdpi.com
SARS-CoV-2 is a novel coronavirus that replicates itself via interacting with the host
proteins. As a result, identifying virus and host protein-protein interactions could help …

Prospects of novel and repurposed immunomodulatory drugs against acute respiratory distress syndrome (ARDS) associated with covid-19 disease

SS Nayak, A Naidu, SL Sudhakaran, S Vino… - Journal of personalized …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is intricately linked with SARS-CoV-2-
associated disease severity and mortality, especially in patients with co-morbidities. Lung …

[HTML][HTML] Host Factor Rab4b Promotes Japanese Encephalitis Virus Replication

Q Zhao, C Miao, YT Chen, LY Zhu, YT Zhang, SQ Luo… - Microorganisms, 2024 - mdpi.com
Although the Japanese encephalitis virus (JEV) infects various cell types, its receptor
molecules are still not clearly understood. In our laboratory's prior research, Rab4b was …

Advances in the development of representation learning and its innovations against COVID-19

P Li, MM Parvej, C Zhang, S Guo, J Zhang - COVID, 2023 - mdpi.com
In bioinformatics research, traditional machine-learning methods have demonstrated
efficacy in addressing Euclidean data. However, real-world data often encompass non …

EPI-SF: essential protein identification in protein interaction networks using sequence features

S Saha, P Chatterjee, S Basu, M Nasipuri - PeerJ, 2024 - peerj.com
Proteins are considered indispensable for facilitating an organism's viability, reproductive
capabilities, and other fundamental physiological functions. Conventional biological assays …

In silico drug discovery: a machine learning-driven systematic review

S Atasever - Medicinal Chemistry Research, 2024 - Springer
This systematic review, which was carried out between 2018 and 2022 in accordance with
PRISMA principles, assesses how machine learning (ML) and other computational …

[PDF][PDF] Identifying Potential Therapeutic Targets in Long COVID Related Inflammatory, Coagulation, Mitochondrial, and Oxidative Stress Pathways through In Silico …

S Kumar, PTA Sigai - 2024 - preprints.org
Long COVID, characterized by persistent symptoms lasting from weeks to several months
following initial infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS …

Identification of Human Drug Targets for COVID-19 Based on Subcellular Localization Information, Gene Expression Data, and Node2vec

C Das, S Saha - International Conference on Frontiers in Computing …, 2023 - Springer
For the last few years, humans have been searching for a good solution to the lethal disease
of COVID-19. Finding human proteins that can be drugged to fight diseases like this is vital …