The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

Immune response to dengue and Zika

A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice

RP dos Santos Alves, J Timis, R Miller… - Nature …, 2024 - nature.com
Abstract SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals.
Human studies indicate these T cells could be elicited by the common cold coronavirus …

Animal models of Zika virus infection, pathogenesis, and immunity

TE Morrison, MS Diamond - Journal of virology, 2017 - Am Soc Microbiol
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics
affecting millions of people on multiple continents. The virus has received global attention …

Current status of Zika virus vaccines: successes and challenges

A Pattnaik, BR Sahoo, AK Pattnaik - Vaccines, 2020 - mdpi.com
The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

The immune response against flaviviruses

JL Slon Campos, J Mongkolsapaya, GR Screaton - Nature immunology, 2018 - nature.com
Arthropod-borne flaviviruses are important human pathogens that cause a diverse range of
clinical conditions, including severe hemorrhagic syndromes, neurological complications …

Current advances in Zika vaccine development

Y Wang, L Ling, Z Zhang, A Marin-Lopez - Vaccines, 2022 - mdpi.com
Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …

Pathogenesis and virulence of flavivirus infections

SW van Leur, T Heunis, D Munnur, S Sanyal - Virulence, 2021 - Taylor & Francis
The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …

Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells

J Wen, WW Tang, N Sheets, J Ellison, A Sette… - Nature …, 2017 - nature.com
CD8+ T cells play an important role in controlling Flavivirus infection, including Zika virus
(ZIKV). Here, we have identified 25 HLA-B* 0702-restricted epitopes and 1 HLA-A* 0101 …