Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …

Unfolded protein response (UPR) is a central stress response pathway that is hijacked by
tumor cells for their survival. Here, we find that IRE1α signaling, one of the canonical UPR …

ARID1A, encoding a subunit of the SWI/SNF complex, is mutated in∼ 50% of clear cell
ovarian carcinoma (OCCC) cases. Here we show that inhibition of the mevalonate pathway …

Clinical diagnosis of ovarian cancer lacks high accuracy due to the weak selection of
specific biomarkers along with the circumstance biomarkers localization. Clustering analysis …

Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …

Protein homeostasis, an important aspect of cellular fitness that encompasses the balance of
production, folding and degradation of proteins, has been linked to several diseases of the …

Background Tumor cells display augmented capability to maintain endoplasmic reticulum
(ER) homeostasis and hijack ER stress pathway for malignant phenotypes under …

High-grade serious ovarian cancer (HGSOC) is an aggressive malignancy that remains
refractory to current immunotherapies. While advanced stage disease has been extensively …

Endoplasmic reticulum (ER) stress, as an emerging hallmark feature of cancer, has a
considerable impact on cell proliferation, metastasis, invasion, and chemotherapy …