Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

This paper introduces a multi-compartment model for microscopic diffusion anisotropy
imaging. The aim is to estimate microscopic features specific to the intra-and extra-neurite …

Myelinating cells surround axons to accelerate the propagation of action potentials, to
support axonal health, and to refine neural circuits. Myelination is metabolically demanding …

The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates
environmental information regarding energy availability and stimulates anabolic molecular …

Accumulating evidence suggests that cerebellar dysfunction early in life is associated with
autism spectrum disorder (ASD), but the molecular mechanisms underlying the cerebellar …

Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder resulting from
autosomal dominant mutations in the TSC1 or TSC2 genes, leading to a hyperactivated …

Recent years have seen a growing interest in relating MRI measurements to the structural-
biophysical properties of white matter fibers. The fiber g-ratio, defined as the ratio between …

MRI is a valuable tool to assess myelin during development and demyelinating disease
processes. While multiexponential T 2 and quantitative magnetization transfer measures …

Disruption of myelination during development has been implicated in a range of
neurodevelopmental disorders including tuberous sclerosis complex (TSC). TSC patients …