Human lesions and animal studies link the claustrum to perception, salience, sleep and pain

H Atilgan, M Doody, DK Oliver, TM McGrath… - Brain, 2022 - academic.oup.com
The claustrum is the most densely interconnected region in the human brain. Despite the
accumulating data from clinical and experimental studies, the functional role of the claustrum …

A role for the claustrum in cognitive control

MB Madden, BW Stewart, MG White… - Trends in cognitive …, 2022 - cell.com
Early hypotheses of claustrum function were fueled by neuroanatomical data and yielded
suggestions that the claustrum is involved in processes ranging from salience detection to …

Brain-state-dependent constraints on claustrocortical communication and function

BA Marriott, AD Do, C Portet, F Thellier, R Goutagny… - Cell reports, 2024 - cell.com
Neural activity in the claustrum has been associated with a range of vigilance states, yet the
activity patterns and efficacy of synaptic communication of identified claustrum neurons have …

Regional and cell-type-specific afferent and efferent projections of the mouse claustrum

Q Wang, Y Wang, HC Kuo, P Xie, X Kuang… - Cell reports, 2023 - cell.com
The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and
subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse …

Pain-induced adaptations in the claustro-cingulate pathway

NR Ntamati, MA Acuña, T Nevian - Cell reports, 2023 - cell.com
Persistent pain is a prevalent medical concern correlating with a hyperexcitable anterior
cingulate cortex (ACC). Its activity is modulated by inputs from several brain regions, but the …

Influence of claustrum on cortex varies by area, layer, and cell type

EG McBride, SR Gandhi, JR Kuyat, DR Ollerenshaw… - Neuron, 2023 - cell.com
The claustrum is a small subcortical structure with widespread connections to disparate
regions of the cortex. However, the impact of the claustrum on cortical activity is not fully …

[HTML][HTML] The claustrum and consciousness: An update

YS Liaw, GJ Augustine - International Journal of Clinical and Health …, 2023 - Elsevier
The seminal paper of Crick and Koch (2005) proposed that the claustrum, an enigmatic and
thin grey matter structure that lies beside the insular cortex, may be involved in the …

The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology

VN Nikolenko, NA Rizaeva, NM Beeraka… - Behavioral and brain …, 2021 - Springer
Introduction The claustrum is a structure involved in formation of several cortical and
subcortical neural microcircuits which may be involved in such functions as conscious …

Advances toward precision therapeutics for developmental and epileptic encephalopathies

I Bertocchi, M Cambiaghi, MT Hasan - Frontiers in Neuroscience, 2023 - frontiersin.org
Developmental and epileptic encephalopathies are childhood syndromes of severe epilepsy
associated with cognitive and behavioral disorders. Of note, epileptic seizures represent …

Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior

CA Faig, GHK Kim, AD Do, Z Dworsky-Fried, J Jackson… - Current Biology, 2024 - cell.com
The anterior cingulate cortex (ACC) is critical for the perception and unpleasantness of pain.
1, 2, 3, 4, 5, 6 It receives nociceptive information from regions such as the thalamus and …