Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Autophagy is an important biological process that is essential for the removal of damaged
organelles and toxic or aggregated proteins by delivering them to the lysosome for …

The 25 years since the identification of the gene responsible for Huntington disease (HD)
have stood witness to profound discoveries about the nature of the disease and its …

Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …

Huntington disease (HD) is a neurodegenerative disorder caused by an elongated
polyglutamine tract in huntingtin (htt). htt normally undergoes different posttranslational …

Cysteinyl aspartate specific proteinase (caspase)‐6 belongs to the caspase family and plays
a vital role in mediating cell death. Under certain conditions, three pathways of programmed …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …