Burns and biofilms: priority pathogens and in vivo models

E Maslova, L Eisaiankhongi, F Sjöberg… - npj Biofilms and …, 2021 - nature.com
Burn wounds can create significant damage to human skin, compromising one of the key
barriers to infection. The leading cause of death among burn wound patients is infection …

Bacteriostatic potential of melatonin: therapeutic standing and mechanistic insights

F He, X Wu, Q Zhang, Y Li, Y Ye, P Li, S Chen… - Frontiers in …, 2021 - frontiersin.org
Diseases caused by pathogenic bacteria in animals (eg, bacterial pneumonia, meningitis
and sepsis) and plants (eg, bacterial wilt, angular spot and canker) lead to high prevalence …

Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach

E Elekhnawy, WA Negm, M El-Aasr, AA Kamer… - Scientific reports, 2022 - nature.com
Pseudomonas aeruginosa is an opportunistic bacterium causing several health problems
and having many virulence factors like biofilm formation on different surfaces. There is a …

[HTML][HTML] Burn-induced local and systemic immune response: systematic review and meta-analysis of animal studies

PPG Mulder, HJPM Koenen, M Vlig, I Joosten… - Journal of Investigative …, 2022 - Elsevier
Because burn injuries are often followed by a derailed immune response and excessive
inflammation, a thorough understanding of the occurring reactions is key to preventing …

Catheter-associated urinary tract infection by Pseudomonas aeruginosa progresses through acute and chronic phases of infection

SA Mekonnen, N El Husseini… - Proceedings of the …, 2022 - National Acad Sciences
Healthcare-associated infections are major causes of complications that lead to extended
hospital stays and significant medical costs. The use of medical devices, including catheters …

Formation of Pseudomonas aeruginosa Biofilms in Full-thickness Scald Burn Wounds in Rats

KS Brandenburg, AJ Weaver Jr, SLR Karna, T You… - Scientific reports, 2019 - nature.com
Abstract Using Sprague-Dawley rats (350–450 g; n= 61) and the recently updated Walker-
Mason rat scald burn model, we demonstrated that Pseudomonas aeruginosa readily …

Evaluation of Pseudomonas aeruginosa pathogenesis and therapeutics in military‐relevant animal infection models

AG Bobrov, D Getnet, B Swierczewski, A Jacobs… - Apmis, 2022 - Wiley Online Library
Modern combat‐related injuries are often associated with acute polytrauma. As a
consequence of severe combat‐related injuries, a dysregulated immune response results in …

Using model systems to unravel host–Pseudomonas aeruginosa interactions

S Grandy, M Scur, K Dolan… - Environmental …, 2023 - Wiley Online Library
Using model systems in infection biology has led to the discoveries of many pathogen‐
encoded virulence factors and critical host immune factors to fight pathogenic infections …

Parallel evolution of Pseudomonas aeruginosa during a prolonged ICU-infection outbreak

DR Cameron, M Pitton, S Oberhaensli… - Microbiology …, 2022 - Am Soc Microbiol
Most knowledge about Pseudomonas aeruginosa pathoadaptation is derived from studies
on airway colonization in cystic fibrosis; little is known about adaptation in acute settings. P …

Comparative Analysis of the Host Response in a Rat Model of Deep-Partial and Full-Thickness Burn Wounds With Pseudomonas aeruginosa Infection

AJ Weaver Jr, KS Brandenburg, BW Smith… - Frontiers in cellular and …, 2020 - frontiersin.org
Burn wound injury affects soldiers and civilians alike, often resulting in a dynamic, but un-
orchestrated, host response that can lead to infection, scarring, and potentially death. To …