Role of homocysteine in the ischemic stroke and development of ischemic tolerance

J Lehotský, B Tothová, M Kovalská, D Dobrota… - Frontiers in …, 2016 - frontiersin.org
Homocysteine (Hcy) is a toxic, sulfur-containing intermediate of methionine metabolism.
Hyperhomocysteinemia (hHcy), as a consequence of impaired Hcy metabolism or defects in …

Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

A Nokkari, H Abou-El-Hassan, Y Mechref… - Progress in …, 2018 - Elsevier
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Pharmacological postconditioning: a molecular aspect in ischemic injury

H Khan, A Kashyap, A Kaur… - Journal of Pharmacy and …, 2020 - academic.oup.com
Abstract Objective Ischaemia/reperfusion (I/R) injury is defined as the damage to the tissue
which is caused when blood supply returns to tissue after ischaemia. To protect the …

Mechanisms involved in the ischemic tolerance in brain: effect of the homocysteine

J Lehotsky, M Petras, M Kovalska, B Tothova… - Cellular and molecular …, 2015 - Springer
Hyperhomocysteinemia (hHCy) is recognized as a co-morbid risk factor of human stroke. It
also aggravates the ischemia-induced injury by increased production of reactive oxygen …

Bradykinin in ischemic conditioning-induced tissue protection: Evidences and possible mechanisms

R Sharma, PK Randhawa, N Singh, AS Jaggi - European Journal of …, 2015 - Elsevier
Ischemic conditioning is an intrinsic protective mechanism in which repeated short episodes
of reversible ischemia protects the tissue and increases its tolerance against a subsequent …

A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway

S Zhang, S Xu, H Duan, Z Zhu, Z Yang, J Cao… - European Journal of …, 2019 - Elsevier
O-succinylapigenin [apigenin-7-O-(6′-O-succinyl)-glucoside], a novel compound, is
identified in chamomile. Although it is highly produced by Bacillus amyloliquefaciens FJ18 …

Protective roles of bioactive peptides during ischemia-reperfusion injury: from bench to bedside

D Wu, J Wang, H Wang, A Ji, Y Li - Life sciences, 2017 - Elsevier
Abstract Ischemia-reperfusion (I/R) is a well-known pathological condition which may lead to
disability and mortality. I/R injury remains an unresolved and complicated situation in a …

[PDF][PDF] Combination of hyperhomocysteinemia and ischemic tolerance in experimental model of global ischemia in rats

M Kovalska, L Kovalska, B Tothova, S Mahmood… - J Physiol …, 2015 - jpp.krakow.pl
Epidemiological studies show positive relationship between mild-to-moderate
hyperhomocysteinemia (hHcy) and the risk of cerebrovascular diseases. The study …

The application and neuroprotective mechanisms of cerebral ischemic post-conditioning: a review

Z Li, H Chen, J Lv, R Zhao - Brain Research Bulletin, 2017 - Elsevier
Ischemic stroke is a serious cerebrovascular disease that leads to death and/or severe
disability, and extensive research has been directed in search of appropriate treatment …

[HTML][HTML] Bradykinin and noradrenaline preconditioning influences level of antioxidant enzymes SOD, CuZn-SOD, Mn-SOD and catalase in the white matter of spinal …

M Danková, I Domoráková, Z Fagová… - European Journal of …, 2019 - ncbi.nlm.nih.gov
The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor)
preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper …