Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour
types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro …

The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …

During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …

WEE1 kinase plays a crucial role in the G2–M cell-cycle checkpoint arrest for DNA repair
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

We describe the cloning of p63, a gene at chromosome 3q27–29 that bears strong
homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a …

The cell cycle is a complex process that involves numerous regulatory proteins that direct
the cell through a specific sequence of events culminating in mitosis and the production of …