Pain is a frequent and poorly treated symptom of Parkinson's disease, mainly due to scarce
knowledge of its basic mechanisms. In Parkinson's disease, deep brain stimulation of the …

In addition to motor symptoms, non-motor manifestations of Parkinson's disease (PD), ie
pain, depression, sleep disturbance, and autonomic disorders, have received increasing …

Background Parkinson's disease (PD) is characterized by Lewy body and neurite pathology
associated with dopamine terminal dysfunction. Clinically, it is associated with motor …

Parkinson's disease (PD) is typicaly caractherized by loss of dopaminergic neurons, as well
as the presence of mitochondrial impairments. Although physical exercise is known to …

Cannabis-inspired medical products are garnering increasing attention from the scientific
community, general public, and health policy makers. A plethora of scientific literature …

Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has
been shown to alleviate the symptoms of PD and, consequently, improve patient quality of …

Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an
oxidative stress–activated calcium channel, was previously reported to be protective in …

Parkinson's disease (PD) is the second most frequent neurodegenerative disease and
currently represents a clear unmet medical need. Therefore, novel preventive and …

Parkinson's disease (PD) is characterized by motor impairment and dopaminergic neuronal
loss. There is no cure for the disease, and treatments have several limitations. The transient …

The origin of pain in PwP remains under investigation. Although our understanding of the
mechanisms underpinning persistent pain in PD has improved in recent years, this has not …