Cutaneous manifestations of internal malignan-cies can be classified pathophysiologically
into direct and indirect effects of cancer. Direct effects are the result of the invasive tumor …

Pityriasis rotunda is an uncommon dermatosis characterized by multiple, widely distributed,
strikingly circular hypopigmented or hyperpigmented patches that are slightly scaly. It has …

The majority of keratinization disorders are referred to as Mendelian disorders of
cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible …

A variety of cutaneous disorders may reflect the presence of an internal disease. The ability
to recognize those that may indicate an underlying malignancy is of particular importance. In …

In an attempt to substantiate the claim that pityriasis rotunda may be a useful cutaneous
marker of hepatocellular carcinoma in South African Blacks, the prevalence of the rash in 63 …

• Although paraneoplastic phenomena occur frequently in patients with hepatocellular
carcinoma, cutaneous changes have rarely been reported. During the past two years, ten …

• The termpityriasis rotundarefers to strikingly circular scaly lesions, with the histologic
appearance of ichthyosis vulgaris. Pityriasis rotunda has been described in the Japanese …

Background: Pityriasis rotunda (PR) is an uncommon dermatosis characterised by multiple,
round or oval, sharply demarcated scaling patches that are dyschromic and asymptomatic. It …

A total of 6,388 medical in‐patients in two South African hospitals, were examined for
pityriasis rotunda. Sixty‐three of 5,800 patients in the rural hospital and two of 588 patients …

Both the occurrence and course of hepatocellular carcinoma (RCC) vary from a rare and
relatively benign tumor, as exemplified in the populations of North America and Europe, to …