Crosstalk between PTEN/PI3K/Akt signalling and DNA damage in the oocyte: implications for primordial follicle activation, oocyte quality and ageing
The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
[HTML][HTML] Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer
B Zhou, Y Yang, X Pang, J Shi, T Jiang… - Biomedicine & …, 2023 - Elsevier
SIRT5 is a mitochondrial NAD+-dependent lysine deacylase. Downregulation of SIRT5 has
been linked to several primary cancers and DNA damage. In clinical therapy for non-small …
been linked to several primary cancers and DNA damage. In clinical therapy for non-small …
Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …
Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
AN Hakeem, DM El-Kersh, O Hammam… - Scientific Reports, 2024 - nature.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
an actionable target with limited treatment options beyond conventional chemotherapy …
an actionable target with limited treatment options beyond conventional chemotherapy …
IP‐Se‐06, a Selenylated Imidazo[1,2‐a]pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF‐1α and MAPK Signaling Inhibition, Promoting …
Glioblastoma multiforme (GBM) is a notably lethal brain tumor associated with high
proliferation rate and therapeutic resistance, while currently effective treatment options are …
proliferation rate and therapeutic resistance, while currently effective treatment options are …
Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques
S Ali, A Noreen, A Qamar, I Zafar, Q Ain… - Frontiers in …, 2023 - frontiersin.org
Cancer is a primary global health concern, and researchers seek innovative approaches to
combat the disease. Clinical bioinformatics and high-throughput proteomics technologies …
combat the disease. Clinical bioinformatics and high-throughput proteomics technologies …
[HTML][HTML] PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease
Huntington's Disease (HD) is a neurodegenerative disease caused by a polyglutamine
(polyQ) expansion in the Huntingtin gene. Astrocyte dysfunction is known to contribute to HD …
(polyQ) expansion in the Huntingtin gene. Astrocyte dysfunction is known to contribute to HD …
A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress
YJ Wei, J Li, ZE Hu, X Xing, ZW Zhou, Y Yu… - Journal of Materials …, 2023 - pubs.rsc.org
Peroxidase (POD)-like nanozymes have been found to act as nanoreactors for the
generation of reactive oxygen species (ROS) to resolve drug resistance in the tumor …
generation of reactive oxygen species (ROS) to resolve drug resistance in the tumor …
Shelterin complex at telomeres: implications in ageing
Different factors influence the development and control of ageing. It is well known that
progressive telomere shorting is one of the molecular mechanisms underlying ageing. The …
progressive telomere shorting is one of the molecular mechanisms underlying ageing. The …