Diverse catalytic reactions for the stereoselective synthesis of cyclic dinucleotide MK-1454
T Benkovics, F Peng, EM Phillips, C An… - Journal of the …, 2022 - ACS Publications
As practitioners of organic chemistry strive to deliver efficient syntheses of the most complex
natural products and drug candidates, further innovations in synthetic strategies are required …
natural products and drug candidates, further innovations in synthetic strategies are required …
Synthesis of rovafovir etalafenamide (part i): Active pharmaceutical ingredient process development, scale-up, and impurity control strategy
EA Standley, DA Bringley, S Calimsiz… - … Process Research & …, 2021 - ACS Publications
This manuscript describes the chemical process development and multi-kilogram synthesis
of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug nucleotide reverse …
of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug nucleotide reverse …
Selective Synthesis of N6,3′,5′-Tripivaloyladenosine via Dynamic Kinetic Crystallization and Regioselective Preparation of Pivalated 2′-Deoxy-2 …
PE Maligres, ZJ Song, L Chen, B Kosjek… - … Process Research & …, 2024 - ACS Publications
A four chemical step route to 2′-deoxy-2′-fluoro-N 6, 3′-dipivaloylarabinoadenosine and
2′-deoxy-2′-fluoro-N 6-pivaloylarabinoadenosine from adenosine was developed for the …
2′-deoxy-2′-fluoro-N 6-pivaloylarabinoadenosine from adenosine was developed for the …
Rovafovir Etalafenamide (Part IV): Synthesis of the Fluorinated Nucleoside Fragment
P Kocienski - Synfacts, 2021 - thieme-connect.com
The fourth and final paper describing Gilead's synthesis of the nucleotide reverse
transcriptase inhibitor rovafovir etalafenamide concerns the elaboration of fluoro glycosyl …
transcriptase inhibitor rovafovir etalafenamide concerns the elaboration of fluoro glycosyl …
[引用][C] The Discovery and Development of MK-1454, a Therapeutic Cyclic Dinucleotide STING Agonist
NS Marzijarani, EM Phillips - 2022 - Elsevier