Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

Background Metformin might reduce insulin requirement and improve glycaemia in patients
with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Abstract Background/Aims: Pancreatogenic, or type 3c, diabetes (T3cDM) occurs due to
inherited or acquired pancreatic disease or resection. Although similar to the more prevalent …

Importance Previous studies assessing the effect of metformin on glycemic control in
adolescents with type 1 diabetes have produced inconclusive results. Objective To assess …

Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime,
with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are …

Aims/hypothesis As adding metformin to insulin therapy has been advocated in type 1
diabetes, we conducted a systematic review of published clinical trials and clinical trial …

摘要背景1 型糖尿病若存在胰岛素抵抗(Insulin resistance, IR) 则提示与慢性糖尿病并发症相关.
我们研究的主要目的是评估合并或者不合并慢性并发症的1 型糖尿病患者的IR …

Diabetes mellitus was the first non-communicable disease that was recognized by the
United Nations as a 21st-century pandemic problem. Recent scientific reports suggest that …