In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1
rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non …

The mechanisms contributing to transcription-associated genomic instability are both
complex and incompletely understood. Although R-loops are normal transcriptional …

Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are
crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Chromosomal double strand breaks provoke an extensive reaction in neighboring
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …