Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Despite the success of LDL-lowering drugs in reducing cardiovascular disease (CVD), there
remains a large burden of residual disease due in part to persistent dyslipidemia …

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …

Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Abstract Purpose of the Review Apolipoprotein (APO) A1, the main apolipoprotein of plasma
high-density lipoproteins (HDLs), has several well documented cardioprotective functions. A …

Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of
cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol …

Accurate quantification of the proteome remains challenging for large sample series and
longitudinal experiments. We report a data-independent acquisition method, Scanning …

Background: Cholesterol loaded macrophage foam cells are a prominent feature of
atherosclerotic plaques. Single-cell RNA sequencing has identified foam cells as TREM2 …

Background: The high-density lipoprotein hypothesis of atherosclerosis has been
challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which …