This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

The KCNE3 β-subunit constitutively opens outwardly rectifying KCNQ1 (Kv7. 1) K+ channels
by abolishing their voltage-dependent gating. The resulting KCNQ1/KCNE3 heteromers …

Extracellular nucleotides interact with purinergic receptors, which regulate ion transport in a
variety of epithelia. With the use of two different human epithelial carcinoma cell lines (HCT8 …

Epithelial cells participate in the immune response of the intestinal mucosa. Extracellular
nucleotides have been recognized as inflammatory molecules. We investigated the role of …

Rationale: Extracellular nucleotides have recently been identified as proinflammatory
mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl−
channel expressed in epithelial cells in the airways, pancreas, intestine and other fluid …

Key points The role of enteric glial cell activity in the acute regulation of epithelial barrier and
secretomotor functions of the intestines under physiological conditions is not clear. We used …