Effects of selection at linked sites on patterns of genetic variability

B Charlesworth, JD Jensen - Annual review of ecology …, 2021 - annualreviews.org
Patterns of variation and evolution at a given site in a genome can be strongly influenced by
the effects of selection at genetically linked sites. In particular, the recombination rates of …

Recommendations for improving statistical inference in population genomics

P Johri, CF Aquadro, M Beaumont, B Charlesworth… - PLoS …, 2022 - journals.plos.org
The field of population genomics has grown rapidly in response to the recent advent of
affordable, large-scale sequencing technologies. As opposed to the situation during the …

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

A Bissett, A Fitzgerald, T Meintjes, PM Mele, F Reith… - GigaScience, 2016 - Springer
Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

Toward an evolutionarily appropriate null model: jointly inferring demography and purifying selection

P Johri, B Charlesworth, JD Jensen - Genetics, 2020 - academic.oup.com
The relative evolutionary roles of adaptive and non-adaptive processes remain a central
question in population genetics. Resolution of this debate has been difficult as an …

Demographic history, selection and functional diversity of the canine genome

EA Ostrander, RK Wayne, AH Freedman… - Nature Reviews …, 2017 - nature.com
The domestic dog represents one of the most dramatic long-term evolutionary experiments
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …

A survey of methods and tools to detect recent and strong positive selection

P Pavlidis, N Alachiotis - Journal of Biological Research-Thessaloniki, 2017 - Springer
Positive selection occurs when an allele is favored by natural selection. The frequency of the
favored allele increases in the population and due to genetic hitchhiking the neighboring …

Detecting recent selective sweeps while controlling for mutation rate and background selection

CD Huber, M DeGiorgio, I Hellmann… - Molecular …, 2016 - Wiley Online Library
A composite likelihood ratio test implemented in the program sweepfinder is a commonly
used method for scanning a genome for recent selective sweeps. sweepfinder uses …

On the unfounded enthusiasm for soft selective sweeps II: examining recent evidence from humans, flies, and viruses

RB Harris, A Sackman, JD Jensen - PLoS genetics, 2018 - journals.plos.org
Since the initial description of the genomic patterns expected under models of positive
selection acting on standing genetic variation and on multiple beneficial mutations—so …

On the unfounded enthusiasm for soft selective sweeps

JD Jensen - Nature communications, 2014 - nature.com
Underlying any understanding of the mode, tempo and relative importance of the adaptive
process in the evolution of natural populations is the notion of whether adaptation is …

The evolutionary history of Nebraska deer mice: local adaptation in the face of strong gene flow

SP Pfeifer, S Laurent, VC Sousa… - Molecular Biology …, 2018 - academic.oup.com
The interplay of gene flow, genetic drift, and local selective pressure is a dynamic process
that has been well studied from a theoretical perspective over the last century. Wright and …