Osteocalcin and its potential functions for preventing fatty liver hemorrhagic syndrome in poultry

W Tu, Y Zhang, K Jiang, S Jiang - Animals, 2023 - mdpi.com
Simple Summary Fatty liver hemorrhage syndrome is one of the main metabolic diseases in
laying hens, which leads to lipid accumulation, fragile liver, rupture bleeding, and sudden …

Expression mapping and functional analysis of orphan G-protein-coupled receptor GPR158 in the adult mouse brain using a GPR158 transgenic mouse

J Chang, Z Song, S Wei, Y Zhou, J Ju, P Yao, Y Jiang… - Biomolecules, 2023 - mdpi.com
Aberrant expression of G-protein-coupled receptor 158 (GPR158) has been reported to be
inextricably linked to a variety of diseases affecting the central nervous system, including …

The emerging roles of GPR158 in the regulation of the endocrine system

J Lin, Q Li, X Lei, H Zhao - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
G protein-coupled receptor 158 (GPR158) is a member of class CG protein-coupled
receptors (GPCRs) and is highly expressed in the central nervous system (CNS) while lowly …

Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling

Q Xiong, Z Zhu, T Li, X Li, Z Zhou, Y Chao… - Nature Structural & …, 2025 - nature.com
Lysosomal membrane protein LYCHOS (lysosomal cholesterol signaling) translates
cholesterol abundance to mammalian target of rapamycin activation. Here we report the …

[HTML][HTML] GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice

S Wei, J Jiang, D Wang, J Chang, L Tian, X Yang… - Cell Reports, 2024 - cell.com
Impairment in social communication skills is a hallmark feature of autism spectrum disorder
(ASD). The role of G-protein-coupled receptor 158 (GPR158) in ASD remains largely …

G protein‐coupled receptor 158 modulates sensitivity to the sedative‐hypnotic effect of ethanol in male mice

S Wei, L Zheng, J Chang, J Jiang… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background Sensitivity to ethanol provides an index of the predisposition to recover from
unconsciousness induced by a dose of ethanol. The role of the G protein‐coupled receptor …

[HTML][HTML] Unlocking the therapeutic capabilities of GPCR in the treatment of ischemic stroke: A translational literature

BS Girish, BS Nikitha, K Roopa, CS Meghana… - Medicine in Drug …, 2024 - Elsevier
GPCRs are a class of membrane proteins that are essential to signal transduction, and this
is a vital process in many different physiologies. The significant mortality rate and …

Glycine: a long-sought novel ligand for GPR158

MM Rosenkilde, JM Mathiesen - Trends in Pharmacological Sciences, 2023 - cell.com
G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse
ligands and varying intracellular coupling partners. Recent work by Laboute et al …

基于内质网应激应答的胶质瘤风险模型构建.

王涛, 陈珂, 周嘉懿, 徐健蓉… - Journal of Practical …, 2023 - search.ebscohost.com
目的探索内质网应激应答(ERS) 相关调控基因表达对胶质瘤(不包括胶质瘤母细胞瘤) 病理分级,
预后和恶性进展表型的预测价值. 方法排除重复和无生存期的样本后, 分别选取美国癌症基因组 …

GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in mice

S Wei, J Chang, J Jiang, J Zhang, D Wang, Y Li… - bioRxiv, 2023 - biorxiv.org
Social novelty impairment is a hallmark feature of autism spectrum disorder associated with
synaptic dysfunction. While G-protein coupled receptor 158 (GPR158) has been shown to …