Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Luminescence bioimaging offers a unique approach for visualizing morphological details of
tissues with subcellular resolution and has become a powerful tool for the manipulation and …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Reactive oxygen species (ROS) are a family of molecules that are continuously generated,
transformed and consumed in all living organisms as a consequence of aerobic life. The …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …