The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

Structural polymeric nanohybrids is presently a popular topic and can be conceived for
numerous functional applications, including the pH-sensitive oral colon-targeted drug …

Fused deposition modeling (FDM) is a 3D printing technique based on the deposition of
successive layers of thermoplastic materials following their softening/melting. Such a …

Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood
sugar levels. However, subcutaneous injection of insulin can lead to patient non …

The development of oral dosage forms that allows absorption of therapeutic peptides to the
systemic circulation is one of the greatest challenges for the pharmaceutical industry …

This article is aimed to overview the lipid-based nanostructures designed so far for the oral
administration of peptides and proteins, and to analyze the influence of their composition …

Many patients with advanced type 2 diabetes mellitus (T2DM) and all patients with T1DM
require insulin to keep blood glucose levels in the target range. The most common route of …

In this study, insulin-loaded nanoparticles (NPs) were prepared via self-gelation method
using chitosan and aqueous soluble snail mucin as natural polymers. Herein, mucins were …

The canonical Wnt pathway is one of the key cellular signaling cascades that regulates, via
the transcriptional co-activator β-catenin, numerous embryogenic developmental processes …