Cell fusion and syncytium formation in betaherpesvirus infection

J Tang, G Frascaroli, X Zhou, J Knickmann, W Brune - Viruses, 2021 - mdpi.com
Cell–cell fusion is a fundamental and complex process that occurs during reproduction,
organ and tissue growth, cancer metastasis, immune response, and infection. All enveloped …

Common polymorphisms in the glycoproteins of human cytomegalovirus and associated strain-specific immunity

HY Wang, SM Valencia, SP Pfeifer, JD Jensen… - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a
common cause of morbidity and mortality for immunocompromised individuals. Recent …

Distribution of CMV envelope glycoprotein B, H and N genotypes in infants with congenital cytomegalovirus symptomatic infection

N Dong, L Cao, D Zheng, L Su, L Lu, Z Dong… - Frontiers in …, 2023 - frontiersin.org
Background Cytomegalovirus (CMV) is the leading cause of congenital infections worldwide
and contributes to long-term sequelae in neonates and children. CMV envelope …

A novel strain-specific neutralizing epitope on glycoprotein H of Human Cytomegalovirus

M Thomas, B Kropff, A Schneider, TH Winkler… - Journal of …, 2021 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe clinical
disease in immunosuppressed patients and congenitally infected newborn infants. Viral …

Development of an aptamer-based electrochemical microfluidic device for viral vaccine quantitation

T Chozinski, BS Ferguson, W Fisher, S Ge… - Analytical …, 2022 - ACS Publications
Global deployment of vaccines poses significant challenges in the distribution and use of the
accompanying immunoassays, one of the standard methods for quality control of vaccines …

Genetic and Functional Characterization of Congenital HCMV Clinical Strains in ex vivo First Trimester Placental Model

D Andouard, V Tilloy, E Ribot, M Mayeras… - Pathogens, 2023 - mdpi.com
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, leading to
a variety of symptoms in the unborn child that range from asymptomatic to death in utero …

“Minimally symptomatic” congenital cytomegalovirus infection: latest data and emerging concepts

A Howard, JK Nishikawa… - Current Opinion in …, 2024 - journals.lww.com
Antiviral therapy with either ganciclovir or valganciclovir has shown moderate benefit in
prevention of hearing deterioration among infants with clinically apparent CMV infection or …

A Virus Genetic System to Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B Variants

X Zhou, G Cimato, Y Zhou, G Frascaroli, W Brune - Viruses, 2023 - mdpi.com
Viruses can induce the fusion of infected and neighboring cells, leading to the formation of
syncytia. Cell–cell fusion is mediated by viral fusion proteins on the plasma membrane of …

[HTML][HTML] Overview of Cytomegalovirus Ocular Diseases: Retinitis, Corneal Endotheliitis, and Iridocyclitis

R Kobayashi, N Hashida - Viruses, 2024 - mdpi.com
Cytomegalovirus (CMV) infection is a significant clinical concern in newborns,
immunocompromised patients with acquired immunodeficiency syndrome (AIDS), and …

Combined knockdown of RL13 and UL128 for release of cell-free infectivity from recent HCMV isolates

N Weiler, KL Sampaio, RJ Stanton, C Sinzger - Journal of Virological …, 2022 - Elsevier
Due to strictly cell-associated growth, experiments requiring cell-free virus are not applicable
to recent clinical HCMV isolates to date. On the other hand, adaptation to cell-free growth is …