From animal models to human individuality: Integrative approaches to the study of brain plasticity

M Hille, S Kühn, G Kempermann, T Bonhoeffer… - Neuron, 2024 - cell.com
Plasticity allows organisms to form lasting adaptive changes in neural structures in response
to interactions with the environment. It serves both species-general functions and …

Common Defects of Spine Dynamics and Circuit Function in Neurodevelopmental Disorders: A Systematic Review of Findings From in Vivo Optical Imaging of Mouse …

N Nakai, T Takumi, J Nakai, M Sato - Frontiers in neuroscience, 2018 - frontiersin.org
In vivo optical imaging is a powerful tool for revealing brain structure and function at both the
circuit and cellular levels. Here, we provide a systematic review of findings obtained from in …

Delayed motor learning in a 16p11. 2 deletion mouse model of autism is rescued by locus coeruleus activation

X Yin, N Jones, J Yang, N Asraoui, ME Mathieu… - Nature …, 2021 - nature.com
Children with autism spectrum disorder often exhibit delays in achieving motor
developmental milestones such as crawling, walking and speech articulation. However, little …

Immunomodulatory actions of cannabinoids: Clinical correlates and therapeutic opportunities for allergic inflammation

AP Nayak, C Loblundo, L Bielory - The Journal of Allergy and Clinical …, 2023 - Elsevier
Endogenously produced cannabinoids as well as phytocannabinoids broadly exhibit anti-
inflammatory actions. Recent emergence of cannabis for multiple medical issues combined …

Inhibition of elevated ras-MAPK signaling normalizes enhanced motor learning and excessive clustered dendritic spine stabilization in the MECP2-duplication …

RT Ash, SA Buffington, J Park, B Suter, M Costa-Mattioli… - eneuro, 2021 - eneuro.org
The inflexible repetitive behaviors and “insistence on sameness” seen in autism imply a
defect in neural processes controlling the balance between stability and plasticity of synaptic …

The roles of motor activity and environmental enrichment in intellectual disability

A De Giorgio - Somatosensory & Motor Research, 2017 - Taylor & Francis
In people with intellectual disabilities, an enriched environment can stimulate the acquisition
of motor skills and could partially repair neuronal impairment thanks to exploration and …

Relationship between synaptic AMPAR and spine dynamics: impairments in the FXS mouse

A Suresh, A Dunaevsky - Cerebral cortex, 2017 - academic.oup.com
Structural dynamics of dendritic spines are important for memory and learning and are
impaired in neurodevelopmental disorders such as fragile X syndrome. Spine dynamics are …

The cellular and molecular basis of in vivo synaptic plasticity in rodents

JE Cheyne, JM Montgomery - American Journal of …, 2020 - journals.physiology.org
Plasticity within the neuronal networks of the brain underlies the ability to learn and retain
new information. The initial discovery of synaptic plasticity occurred by measuring synaptic …

Excessive formation and stabilization of dendritic spine clusters in the mecp2-duplication syndrome mouse model of autism

RT Ash, J Park, B Suter, HY Zoghbi, SM Smirnakis - ENeuro, 2021 - eneuro.org
Autism-associated genetic mutations may perturb the balance between stability and
plasticity of synaptic connections in the brain. Here, we report an increase in the formation …

Evidence for a contribution of the Nlgn3/Cyfip1/Fmr1 pathway in the pathophysiology of autism spectrum disorders

M Sledziowska, J Galloway, SJ Baudouin - Neuroscience, 2020 - Elsevier
Abstract Autism Spectrum Disorders (ASD) are characterized by heterogeneity both in their
presentation and their genetic aetiology. In order to discover points of convergence common …