Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells.
However, master regulators of apoptosis (eg, p53, p16/CDKN2A) are frequently genetically …

Intracellular pathogens such as viruses and bacteria subvert all the major cellular functions
of their hosts. Targeted host processes include protein synthesis, membrane trafficking …

The epigenetics of host–pathogen interactions is emerging as an interesting angle from
which to study how parasites have evolved sophisticated strategies to manipulate host gene …

The apicomplexan parasites Theileria annulata and Theileria parva cause severe
lymphoproliferative disorders in cattle. Disease pathogenesis is linked to the ability of the …

The modulation of apoptosis has emerged as an important weapon in the pathogenic
arsenal of multiple intracellular protozoan parasites. Cryptosporidium parvum, Leishmania …

Programmed cell death (PCD) is a potent mechanism to remove parasitized cells, but it has
also been shown that protozoan parasites can induce or inhibit apoptosis in host cells. In …

The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique
capacity to transform the cells it infects, inducing continuous proliferation and protection …

The intracellular stages of apicomplexan parasites are known to extensively modify their
host cells to ensure their own survival. Recently, considerable progress has been made in …

Theileria parasites infect and transform bovine lymphocytes resulting in tumors with
metastatic/invasive potential. Importantly, cellular transformation is reversed upon drug …

Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in
the hostile environment within host cells. Unicellular, eukaryotic parasites from the …