Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

F Ahmed, IS Kang, KH Kim, A Asif… - Journal of Medical …, 2023 - Wiley Online Library
Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …

[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing

F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

Targeting breast cancer stem cells through retinoids: a new hope for treatment

N Jan, S Sofi, H Qayoom, BU Haq, A Shabir… - Critical Reviews in …, 2023 - Elsevier
Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …

Targeting KRAS in colorectal cancer: a bench to bedside review

F Bteich, M Mohammadi, T Li, MA Bhat… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

Preclinical and clinical trials of new treatment strategies targeting cancer stem cells in subtypes of breast cancer

N Landeros, I Castillo, R Pérez-Castro - Cells, 2023 - mdpi.com
Breast cancer (BC) can be classified into various histological subtypes, each associated with
different prognoses and treatment options, including surgery, radiation, chemotherapy, and …

Drug repurposing against KRAS mutant G12C: a machine learning, molecular docking, and molecular dynamics study

T Srisongkram, N Weerapreeyakul - International Journal of Molecular …, 2022 - mdpi.com
The Kirsten rat sarcoma viral G12C (KRASG12C) protein is one of the most common
mutations in non-small-cell lung cancer (NSCLC). KRASG12C inhibitors are promising for …

[HTML][HTML] Network-based drug repurposing for HPV-associated cervical cancer

F Ahmed, YJ Yang, A Samantasinghar, YW Kim… - Computational and …, 2023 - Elsevier
In women, cervical cancer (CC) is the fourth most common cancer around the world with
average cases of 604,000 and 342,000 deaths per year. Approximately 50% of high-grade …

Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer

F Ahmed, A Samantasinghar, W Ali, KH Choi - Molecular Diversity, 2024 - Springer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone
in the United States (US), 66,200 new cases and 13,030 deaths are expected to occur in …

Therapeutic Options for Chlamydia trachomatis Infection: Present and Future

R Rodrigues, L Marques, P Vieira-Baptista, C Sousa… - Antibiotics, 2022 - mdpi.com
Sexually transmitted infections (STIs), such as Chlamydia trachomatis (Ct) infection, have
serious consequences for sexual and reproductive health worldwide. Ct is one of the most …