Intervertebral disc degeneration: biomaterials and tissue engineering strategies toward precision medicine

IL Mohd Isa, SA Mokhtar, SA Abbah… - Advanced …, 2022 - Wiley Online Library
Intervertebral disc degeneration is a common cause of discogenic low back pain resulting in
significant disability. Current conservative or surgical intervention treatments do not reverse …

Mitochondrial quality control in intervertebral disc degeneration

Y Song, S Lu, W Geng, X Feng, R Luo, G Li… - … & molecular medicine, 2021 - nature.com
Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the
human lifespan that can increase the risk of low back pain. More clarification of the …

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

H Xing, Z Zhang, Q Mao, C Wang, Y Zhou… - Journal of …, 2021 - Springer
Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration
(IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the …

Cell sources proposed for nucleus pulposus regeneration

RJ Williams, MA Tryfonidou, JW Snuggs… - JOR …, 2021 - Wiley Online Library
Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of
the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration …

[HTML][HTML] Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal …

Z Wang, H Yang, X Xu, H Hu, Y Bai, J Hai, L Cheng… - Bioactive Materials, 2023 - Elsevier
Chronic low back pain and dyskinesia caused by intervertebral disc degeneration (IDD) are
seriously aggravated and become more prevalent with age. Current clinical treatments do …

Notochordal cell-based treatment strategies and their potential in intervertebral disc regeneration

FC Bach, DW Poramba-Liyanage… - Frontiers in Cell and …, 2022 - frontiersin.org
Chronic low back pain is the number one cause of years lived with disability. In about 40% of
patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The …

Critical aspects and challenges for intervertebral disc repair and regeneration—Harnessing advances in tissue engineering

CT Buckley, JA Hoyland, K Fujii, A Pandit… - Jor …, 2018 - Wiley Online Library
Low back pain represents the highest burden of musculoskeletal diseases worldwide and
intervertebral disc degeneration is frequently associated with this painful condition. Even …

[HTML][HTML] Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model

D Sheyn, S Ben-David, W Tawackoli, Z Zhou… - Theranostics, 2019 - ncbi.nlm.nih.gov
Introduction: As many as 80% of the adult population experience back pain at some point in
their lifetimes. Previous studies have indicated a link between back pain and intervertebral …

Notochordal cells: A potential therapeutic option for intervertebral disc degeneration

Y Li, H Zhang, D Zhu, F Yang, Z Wang, Z Wei… - Cell …, 2024 - Wiley Online Library
Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal degenerative disorder
worldwide, and~ 40% of chronic low back pain cases are associated with IDD. Although the …

Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration

X Zhou, J Wang, X Huang, W Fang, Y Tao, T Zhao… - Acta biomaterialia, 2018 - Elsevier
Stem cell-based tissue engineering is a promising treatment for intervertebral disc (IVD)
degeneration. A bio-scaffold that can maintain the function of transplanted cells and …