Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses

AI Benítez-Mateos, D Roura Padrosa, F Paradisi - Nature chemistry, 2022 - nature.com
Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Putting precision and elegance in enzyme immobilisation with bio-orthogonal chemistry

X Pei, Z Luo, L Qiao, Q Xiao, P Zhang… - Chemical Society …, 2022 - pubs.rsc.org
The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications

B Yuan, D Yang, G Qu, NJ Turner, Z Sun - Chemical Society Reviews, 2024 - pubs.rsc.org
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase

J Xu, J Fan, Y Lou, W Xu, Z Wang, D Li, H Zhou… - Nature …, 2021 - nature.com
Despite the well-established chemical processes for CD bond formation, the toolbox of
enzymatic methodologies for deuterium incorporation has remained underdeveloped. Here …

Process intensification as game changer in enzyme catalysis

BO Burek, AWH Dawood, F Hollmann, A Liese… - Frontiers in …, 2022 - frontiersin.org
Enzyme catalysis, made tremendous progress over the last years in identification of new
enzymes and new enzymatic reactivity's as well as optimization of existing enzymes …

Cell-free enzyme cascades—application and transition from development to industrial implementation

M Teshima, VP Willers, V Sieber - Current Opinion in Biotechnology, 2023 - Elsevier
Highlights•State-of-the-art in vitro enzyme cascades to assimilate CO 2-derived C1
compounds.•Current transitioning state of the biomass-based production of commodity …

Interfacially synthesized 2D COF thin film photocatalyst: efficient photocatalyst for solar formic acid production from CO 2 and fine chemical synthesis

D Yadav, A Kumar, JY Kim, NJ Park… - Journal of Materials …, 2021 - pubs.rsc.org
The targeted synthesis of an efficient, visible light active, recyclable, freestanding covalent
organic framework thin film photocatalyst for multi-faceted photocatalysis is the essence of …

[HTML][HTML] Recent advances in oxidase biocatalysts: Enzyme discovery, cascade reactions and scale up

RS Heath, NJ Turner - Current Opinion in Green and Sustainable …, 2022 - Elsevier
Enzymatic oxidation reactions may offer 'greener'alternatives to chemical oxidation
processes, which have typically involved toxic metal catalysts, generation of toxic byproducts …

Recent advances in biocatalysis of nitrogen-containing heterocycles

J Feng, WC Geng, H Jiang, B Wu - Biotechnology Advances, 2022 - Elsevier
Nitrogen-containing heterocycles (N-heterocycles) are ubiquitous in both organisms and
pharmaceutical products. Biocatalysts are providing green approaches for synthesizing …