The molecular basis of fertilization

K Georgadaki, N Khoury… - International …, 2016 - spandidos-publications.com
Fertilization is the fusion of the male and female gamete. The process involves the fusion of
an oocyte with a sperm, creating a single diploid cell, the zygote, from which a new …

Sperm-egg fusion: a molecular enigma of mammalian reproduction

K Klinovska, N Sebkova… - International journal of …, 2014 - mdpi.com
The mechanism of gamete fusion remains largely unknown on a molecular level despite its
indisputable significance. Only a few of the molecules required for membrane interaction are …

Energy metabolism and hyperactivation of spermatozoa from three mouse species under capacitating conditions

E Sansegundo, M Tourmente, ERS Roldan - Cells, 2022 - mdpi.com
Mammalian sperm differ widely in sperm morphology, and several explanations have been
presented to account for this diversity. Less is known about variation in sperm physiology …

Internalization of silver nanoparticles into mouse spermatozoa results in poor fertilization and compromised embryo development

T Yoisungnern, YJ Choi, J Woong Han, MH Kang… - Scientific reports, 2015 - nature.com
Silver nanoparticles (AgNPs) have many features that make them attractive as medical
devices, especially in therapeutic agents and drug delivery systems. Here we have …

Role of integrins in sperm activation and fertilization

V Merc, M Frolikova, K Komrskova - International Journal of Molecular …, 2021 - mdpi.com
In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a
large group of cell adhesion receptors involved in cell–cell, cell–extracellular matrix, and cell …

Trophoblast development

PL Pfeffer, DJ Pearton - Reproduction, 2012 - rep.bioscientifica.com
This study examines the impacts of the urokinase-type plasminogen activator (uPA) on the in
vitro maturation (IVM) of bovine oocytes. Cumulus–oocyte complexes in IVM medium were …

Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A2 activity impair the in vitro sperm fertilizing competence in mice

AR Moawad, MC Fernandez, E Scarlata, C Dodia… - Scientific Reports, 2017 - nature.com
Abstract Prdx6−/− male mice are subfertile, and the deficiency or inactivation of
Peroxiredoxins (PRDXs) is associated with human male infertility. We elucidate the impact of …

Mechanisms that protect mammalian sperm from the spontaneous acrosome reaction

H Breitbart, E Grinshtein - International Journal of Molecular Sciences, 2023 - mdpi.com
To acquire the capacity to fertilize the oocyte, mammalian spermatozoa must undergo a
series of biochemical reactions in the female reproductive tract, which are collectively called …

[HTML][HTML] Proteomic analysis of the mouse sperm acrosome-towards an understanding of an organelle with diverse functionality

T Otčenášková, E Macíčková, J Vondráková… - European Journal of …, 2023 - Elsevier
The acrosome located within the mammalian sperm head is essential for successful
fertilization, as it enables the sperm to penetrate the extracellular layers of the oocyte and …

Proteomics of reproductive systems: towards a molecular understanding of postmating, prezygotic reproductive barriers

CE McDonough, E Whittington, S Pitnick, S Dorus - Journal of Proteomics, 2016 - Elsevier
Following mating and insemination, fertility is dependent on the successful execution of a
complex array of morphological, physiological and molecular interactions between male and …