Protein-based therapeutics are highly successful in clinic and currently enjoy
unprecedented recognition of their potential. More than 100 genuine and similar number of …

Background Tumor necrosis factor (TNF) inhibitors are a mainstay in the treatment of
rheumatoid arthritis (RA), as well as in the management of spondyloarthritis (SpA) and …

Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and
systemic flushing accompanied by extensive sterile pustules. The committee of the …

Antibody-based drugs such as infliximab (IFX) are effective for the treatment of inflammatory
bowel disease (IBD) and other immune-mediated disorders. The development of antibodies …

The introduction of anti-tumour necrosis factor (TNF) agents for the treatment of rheumatoid
arthritis (RA), Crohn's disease (CD) or spondyloarthritis (SpA) has revolutionised the …

Antidrug antibodies (ADAs) against biological agents may be clinically significant and
potentially alter a biological drug's treatment efficacy. This systematic review aims to (i) …

Psoriasis is a multifactorial recalcitrant inflammatory skin disease characterized by
bothersome scaly reddish plaques especially on frequently chafed body parts, such as the …

Importance Knowledge of the immunogenicity of biologic agents may be helpful for the
development of strategies for treatment of chronic immune-mediated inflammatory diseases …

Objective To evaluate the associations between (1) antidrug antibody (ADAb) and
therapeutic response,(2) ADAb and serum drug trough levels and (3) serum drug levels and …

BACKGROUND: In vitro testing is commonly used to diagnose and manage allergies.
Clinical reactivity has been correlated with food-specific IgE levels by using the ImmunoCAP …